Search results for "T cell selection"

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Antigen-Driven T-Cell Selection in Patients with Cervical Cancer as Evidenced by T-Cell Receptor Analysis and Recognition of Autologous Tumor

2002

ABSTRACTWe characterized the T-cell receptor (TCR) repertoire in freshly harvested tumor lesions, in short-term-expanded CD4+tumor infiltrating lymphocytes (TIL) as well as in CD4+and CD8+peripheral blood lymphocytes (PBL) from three patients with cervical cancer. Skewing of the T-cell repertoire as defined by measuring the length of the complementarity-determining region 3 (CDR3) of the TCR VA and VB chains was observed in CD8+PBL, in freshly harvested tumor tissue, as well as in CD4+TIL. Comparative analysis of the TCR repertoire revealed unique monoclonal TCR transcripts within the tumor lesion which were not present in PBL, suggesting selection of TCR clonotypes due to antigenic stimula…

CD4-Positive T-LymphocytesMicrobiology (medical)medicine.medical_treatmentClinical BiochemistryImmunologyReceptors Antigen T-CellUterine Cervical Neoplasmschemical and pharmacologic phenomenaCD8-Positive T-LymphocytesBiologyEpitopeEpitopesLymphocytes Tumor-InfiltratingImmune systemAntigenAntigens NeoplasmExperimental Clinical InvestigationmedicineHumansImmunology and AllergyTumor-infiltrating lymphocytesT-cell receptorhemic and immune systemsImmunotherapyComplementarity Determining RegionsImmunologyT cell selectionFemaleCD8Clinical and Vaccine Immunology
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